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Article

Lack of variation in the nucleotide sequence corresponding to the transmembrane domain of the beta-amyloid precursor protein in Alzheimer's disease.

American journal of medical genetics - 15 Oct 1993

Zubenko G S, Stiffler S, Farr J, Kopp U, Hughes H, Kaplan B B, Moossy J

Abstract excerpt

The nucleotide sequence corresponding to the APP transmembrane domain and flanking regions of charged amino acids was determined for 91 patients with histologically confirmed Alzheimer's disease, 9 patients with dementias of other etiologies, and 14 controls who had no identifiable brain disease....

Topics

Alzheimer Disease
Amino Acid Sequence
Amyloid beta-Protein Precursor
Base Sequence
Genetic Testing
Genetic Variation
Membrane Proteins
Molecular Sequence Data
Mutation
Protein Structure, Tertiary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8291566
DOI: 10.1002/ajmg.1320480304

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8291566-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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