Article
The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.
Neuroscience letters - 9 Jan 2006
Brouwers Nathalie, Sleegers Kristel, Engelborghs Sebastiaan, Bogaerts Veerle, van Duijn Cornelia M, De Deyn Peter Paul, Van Broeckhoven Christine, Dermaut Bart
Abstract excerpt
An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of patients with an onset age 70 years or less, but did not observe statistically significant...
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