Identification of the photocrosslinking sites in troponin-I with 4-maleimidobenzophenone labelled mutant troponin-Cs having single cysteines at positions 158 and 21.

doi:10.1023/a:1005352324741

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Article

Identification of the photocrosslinking sites in troponin-I with 4-maleimidobenzophenone labelled mutant troponin-Cs having single cysteines at positions 158 and 21.

Journal of muscle research and cell motility - 1 Jun 1998

Leszyk J, Tao T, Nuwaysir L M, Gergely J

Abstract excerpt

Our previous studies have shown that 4-maleimidobenzophenone (BP-Mal) attached to troponin-C (TnC) mutants with single cysteines at positions 12, 57, 89 and 98 forms crosslinks to troponin-I (TnI), and the identified crosslinking regions indicate an antiparallel course of the two interacting poly...

Topics

Amino Acid Sequence
Animals
Benzophenones
Chromatography, High Pressure Liquid
Cysteine
Maleimides
Models, Chemical
Muscle, Skeletal
Mutation
Peptide Mapping
Rabbits
Spectrophotometry
Structure-Activity Relationship
Troponin C
Troponin I

Source

Open in PubMed

Identifiers

PMID: 9682135
DOI: 10.1023/a:1005352324741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9682135-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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