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Article

An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.

Biochemistry - 1 Mar 1994

Harrison D H, Bohren K M, Ringe D, Petsko G A, Gabbay K H

Abstract excerpt

Aldose reductase is a NADPH-dependent aldo-keto reductase involved in the pathogenesis of some diabetic and galactosemic complications. The published crystal structure of human aldose reductase [Wilson et al. (1992) Science 257, 81-84] contains a hitherto unexplained electron density positioned within the active site pocket facing the nicotinamide ring of the NADPH and other key active site residues (Tyr48,...

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PMID: 8117658
DOI: 10.1021/bi00174a006

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