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Article

On the catalytic mechanism of human ATP citrate lyase.

Biochemistry - 26 Jun 2012

Fan Fan, Williams Howard J, Boyer Joseph G, Graham Taylor L, Zhao Huizhen, Lehr Ruth, Qi Hongwei, Schwartz Benjamin, Raushel Frank M, Meek Thomas D

Abstract excerpt

ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA). Studies were performed with recombinant human ACL to ascertain the nature of the catalytic phosphorylation that initiates the ACL reaction and the identity of the active site residues involved. Inactivation of ACL by treatment with diethylpyrocarbonate...

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PMID: 22657152
DOI: 10.1021/bi300611s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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