Article
Overexpression of an ectopic H19 gene enhances the tumorigenic properties of breast cancer cells.
Carcinogenesis - 1 Nov 2002
Lottin Séverine, Adriaenssens Eric, Dupressoir Thierry, Berteaux Nathalie, Montpellier Claire, Coll Jean, Dugimont Thierry, Curgy Jean Jacques
Abstract excerpt
The maternally expressed H19 gene is transcribed as an untranslated RNA that serves as a riboregulator. We have previously reported that this transcript accumulates in epithelial cells in approximately 10% of breast cancers. To gain further insight on how the overexpression of the H19 gene affects the phenotype of human breast epithelial cells, we investigated the oncogenic potential of RNA that was abundantly...
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