Article
Molecular analysis of the immune response to human cytomegalovirus glycoprotein B (gB). II. Low gB-specific T and B cell responses are associated with expression of certain HLA-DR alleles.
The Journal of general virology - 1 Feb 1994
Curtsinger J M, Liu Y N, Radeke R, Bryon M K, Fuad S, Bach F H, Gehrz R C
Abstract excerpt
Human cytomegalovirus (HCMV) is a common cause of congenital infection leading to birth defects and a leading cause of serious illness in patients with immunodeficiencies. Studies in this laboratory have focused on a molecular analysis of the immune response to glycoprotein B (gB) of HCMV. This protein has been shown to elicit B cell, helper T cell (Th), and cytotoxic T cell responses, suggesting that it may be...
Topics
- Adult
- Alleles
- B-Lymphocytes
- Cell Line
- Cytomegalovirus
- HLA-DR Antigens
- Humans
- Lymphocyte Activation
- T-Lymphocytes
- Viral Envelope Proteins