Article
Molecular analysis of the immune response to human cytomegalovirus glycoprotein B. I. Mapping of HLA-restricted helper T cell epitopes on gp93.
The Journal of general virology - 1 Oct 1993
Liu Y N, Curtsinger J, Donahue P R, Klaus A, Optiz G, Cooper J, Karr R W, Bach F H, Gehrz R C
Abstract excerpt
Human cytomegalovirus (HCMV) is one of the most common causes of congenital infection leading to birth defects, and a leading cause of serious illness in patients with impaired cell-mediated immunity. Helper T cell (Th) responses to HCMV proteins are likely to be important in limiting viral replication and preventing disease. Previous studies from this laboratory have demonstrated that the amino-terminal 513...
Topics
- Adult
- Alleles
- Antigens, Viral
- Cytomegalovirus
- Epitopes
- Glycoproteins
- HLA-D Antigens
- Humans
- Peptide Mapping
- Polymorphism, Genetic
- Sensitivity and Specificity