Article
Polymorphisms in Toll-like receptor genes influence antibody responses to cytomegalovirus glycoprotein B vaccine.
BMC research notes - 13 Mar 2012
Arav-Boger Ravit, Wojcik Genevieve L, Duggal Priya, Ingersoll Roxann G, Beaty Terri, Pass Robert F, Yolken Robert H
Abstract excerpt
BACKGROUND: Congenital Cytomegalovirus (CMV) infection is an important medical problem that has yet no current solution. A clinical trial of CMV glycoprotein B (gB) vaccine in young women showed promising efficacy. Improved understanding of the basis for prevention of CMV infection is essential for developing improved vaccines. RESULTS: We genotyped 142 women previously vaccinated with three doses of CMV gB for...
Topics
- Adult
- Alleles
- Antibodies, Viral
- Cohort Studies
- Cytomegalovirus
- Cytomegalovirus Infections
- Cytomegalovirus Vaccines
- Female
- Genotype
- Heterozygote
- Homozygote