Article

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses

2022-11-29

Abstract excerpt

Human cytomegalovirus (HCMV) remains the most common congenital infection and infectious complication in immunocompromised patients. The most successful HCMV vaccine to-date, an HCMV glycoprotein B (gB) subunit vaccine adjuvanted with MF59, achieved 50% efficacy against primary HCMV infection. A previous study demonstrated that gB/MF59 vaccinees were less frequently infected with HCMV gB genotype strains most simi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2a95a00-3750-576e-976e-31372e1e6f67
DOI: 10.1101/2022.11.23.517695

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody ResponsesDOI 10.1101/2022.11.23.517695Read

Multivalent cytomegalovirus glycoprotein B nucleoside modified mRNA vaccines did not demonstrate a greater antibody breadthSemantic proximity Read

Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody ResponsesSemantic proximity Read

Human Cytomegalovirus mRNA-1647 Vaccine Candidate Elicits Potent and Broad Neutralization and Higher Antibody-Dependent Cellular Cytotoxicity Responses Than the gB/MF59 VaccineSemantic proximity Read

HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functionsSemantic proximity Read

HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functionsSemantic proximity Read

Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infectionSemantic proximity Read

Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humansSemantic proximity Read

Vaccination with a disabled infectious single cycle cytomegalovirus vaccine elicits a distinct glycoprotein B-specific monoclonal antibody repertoire compared to that of naturally-infected individualsSemantic proximity Read

Genetic signatures of human cytomegalovirus variants acquired by seronegative glycoprotein B vaccineesSemantic proximity Read

LNP-CpG: deploy the self-adjuvant role of mRNA vaccinesSemantic proximity Read

Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer ComplexSemantic proximity Read

Characterization of humoral and cellular immunologic responses to an mRNA-based human cytomegalovirus vaccine from a phase 1 trial of healthy adultsSemantic proximity Read