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Article

Importance of the proline-rich region following signal-anchor sequence in the formation of correct conformation of microsomal cytochrome P-450s.

Journal of biochemistry - 1 Nov 1993

Yamazaki S, Sato K, Suhara K, Sakaguchi M, Mihara K, Omura T

Abstract excerpt

A proline-rich region is present following the signal-anchor sequence in the amino-terminal portion of all known microsomal cytochrome P-450s. To assess the functional significance of the proline residues in this region, we systematically altered these residues of cytochrome P450(M1) (P450 2C11); one, two, and three proline residues out of the five in the region were exchanged for alanine residues. The wild-type...

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PMID: 8113216
DOI: 10.1093/oxfordjournals.jbchem.a124232

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