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Article

A highly active single-mutation variant of P450BM3 (CYP102A1).

Chembiochem : a European journal of chemical biology - 6 Jul 2009

Whitehouse Christopher J C, Bell Stephen G, Yang Wen, Yorke Jake A, Blanford Christopher F, Strong Anthony J F, Morse Edward J, Bartlam Mark, Rao Zihe, Wong Luet-Lok

Abstract excerpt

The power of proline: Bold amino acid substitutions in sensitive protein regions are frequently unproductive, while more subtle mutations can be sufficient to bring about dramatic changes. But introducing proline at the residue next to the sulfur ligand in P450(BM3) (CYP102A1) has the unexpected and desirable effect of enhancing the activity of this fatty acid hydroxylase with a broad range of non-natural...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19492389
DOI: 10.1002/cbic.200900279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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