A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells.

Experimental hematology - 1 Mar 1994

Friend S L, Hosier S, Nelson A, Foxworthe D, Williams D E, Farr A

Abstract excerpt

A thymic stromal cell line with a medullary phenotype (Z210R.1) supported the differentiation of surface IgM+ B cells when cocultured with fetal liver cells in vitro. Conditioned medium (CM) from this cell line supported the long-term growth of a B cell line (NAG8/7) isolated from cocultures and...

Topics

Animals
Antibodies, Monoclonal
B-Lymphocytes
CD3 Complex
Cell Communication
Cell Differentiation
Cell Line
Chromatography, Ion Exchange
Culture Media, Conditioned
Flow Cytometry
Growth Substances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoiesis

Immunoglobulin M

Interleukin-7

Liver

Mice

Mice, Inbred BALB C

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8112430

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8112430-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells.PMID 8112430Read ↗

Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.Semantic proximity Read ↗

Culture of human fetal B-cell precursors on bone marrow stroma maintains highly proliferative CD20dim cells.Semantic proximity Read ↗

Support of early B-cell differentiation in mouse fetal liver by stromal cells and interleukin-7.Semantic proximity Read ↗

Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture.Semantic proximity Read ↗

Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environmentSemantic proximity Read ↗

Interleukin 7 independent development of human B cells.Semantic proximity Read ↗

Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors.Semantic proximity Read ↗

Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases.Semantic proximity Read ↗

Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.Semantic proximity Read ↗

Functional coexpression of Interleukin (IL)‐7 and its receptor (IL‐7R) on Hodgkin and Reed‐Sternberg cells: Involvement of IL‐7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphomaSemantic proximity Read ↗

Rat thymic epithelial cells in culture constitutively secrete IL-1 and IL-6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.