Article
Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1994
Komschlies K L, Gregorio T A, Gruys M E, Back T C, Faltynek C R, Wiltrout R H
Abstract excerpt
These studies investigate the effects of exogenously administered recombinant human IL-7 (rhIL-7) on mouse leukocyte subsets in vivo in normal and tumor-bearing mice. The administration of rhIL-7 to normal mice caused a pronounced leukocytosis (three- to fivefold increase over background) in the spleen and lymph nodes, with B-lineage and T cells, NK cells, and macrophages all being increased. CD8+ T cells...
Topics
- Animals
- Antigens, Differentiation
- B-Lymphocytes
- Carcinoma, Renal Cell
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Immunologic
- Humans
- Interleukin-7
- Kidney Neoplasms
- Mice