Article
Mechanism of action of developmentally regulated sea urchin inhibitor of eIF-4.
Developmental genetics - 1 Jan 1993
Jagus R, Huang W, Hiremath L S, Stern B D, Rhoads R E
Abstract excerpt
The developmentally regulated inhibitor of eIF-4 function found in unfertilized sea urchin eggs has been partially purified and its mechanism of action studied in vitro using purified recombinant eIF-4 alpha and cell-free translation systems. The results demonstrate that although the phosphorylation of eIF-4 alpha is necessary to promote protein synthesis, it is not sufficient to maintain all aspects of eIF-4...
Topics
- Animals
- Female
- Fertilization
- Genetic Variation
- Oocytes
- Peptide Initiation Factors
- Phosphorylation
- Protein Biosynthesis
- RNA, Messenger
- Recombinant Proteins
- Ribosomes
- Sea Urchins