Article
The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcription.
Molecular and cellular biology - 1 Apr 1995
Wang Z, Buratowski S, Svejstrup J Q, Feaver W J, Wu X, Kornberg R D, Donahue T F, Friedberg E C
Abstract excerpt
The essential TFB1 and SSL1 genes of the yeast Saccharomyces cerevisiae encode two subunits of the RNA polymerase II transcription factor TFIIH (factor b). Here we show that extracts of temperature-sensitive mutants carrying mutations in both genes (tfb1-101 and ssl1-1) are defective in nucleotide excision repair (NER) and RNA polymerase II transcription but are proficient for base excision repair. RNA polymerase...
Topics
- Base Sequence
- DNA Repair
- Dose-Response Relationship, Radiation
- Fungal Proteins
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- RNA Polymerase II
- Radiation Tolerance
- Saccharomyces cerevisiae