Article
Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2011
Moriel-Carretero María, Tous Cristina, Aguilera Andrés
Abstract excerpt
Yeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform NER initial steps but not late steps of postincision gap filing. Because removal of early-acting NER proteins prevents rad3-102 deleterious action, we used this feature to explore if chaperones act in early NER. We found that the cochaperone Ydj1 is required for NER and that Ydj1 guarantees...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.