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Article

Sodium channel inactivation is impaired in equine hyperkalemic periodic paralysis.

Journal of neurophysiology - 1 May 1995

Cannon S C, Hayward L J, Beech J, Brown R H

Abstract excerpt

1. Equine hyperkalemic periodic paralysis (E-HPP) is a dominantly inherited disorder of muscle that causes recurrent episodes of stiffness (myotonia) and weakness in association with elevated serum K+. Affected horses carry a mutant allele of the skeletal muscle isoform of the Na channel alpha-subunit. To understand how this mutation may cause the disease phenotype, the functional defect in Na channel behavior...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7623088
DOI: 10.1152/jn.1995.73.5.1892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Sodium channel inactivation is impaired in equine hyperkalemic periodic paralysis.PMID 7623088Read ↗

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NaV1.4 DI-S4 periodic paralysis mutation R222W enhances inactivation and promotes leak current to attenuate action potentials and depolarize muscle fibers.Semantic proximity Read ↗

Functional expression of sodium channel mutations identified in families with periodic paralysis.Semantic proximity Read ↗

Periodic paralysis.Semantic proximity Read ↗

A C‐terminal skeletal muscle sodium channel mutation associated with myotonia disrupts fast inactivationSemantic proximity Read ↗

Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4-S5.Semantic proximity Read ↗

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K(+)-aggravated myotonia: destabilization of the inactivated state of the human muscle Na+ channel by the V1589M mutation.Semantic proximity Read ↗

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