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Article

The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states.

The Journal of physiology - 1 Dec 1996

Hanna W J, Tsushima R G, Sah R, McCutcheon L J, Marban E, Backx P H

Abstract excerpt

1. The Na+ channel mutation associated with equine hyperkalaemic periodic paralysis (HPP) affects a highly conserved phenylalanine residue in an unexplored region of the alpha-subunit. This mutation was introduced into the rat skeletal muscle Na+ channel gene at the corresponding location (i.e. F1412L) for functional expression and characterization in Xenopus oocytes. 2. In comparison with wild-type (WT)...

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Identifiers

PMID: 8961180
DOI: 10.1113/jphysiol.1996.sp021773
PMCID: PMC1160989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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