Article
The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states.
The Journal of physiology - 1 Dec 1996
Hanna W J, Tsushima R G, Sah R, McCutcheon L J, Marban E, Backx P H
Abstract excerpt
1. The Na+ channel mutation associated with equine hyperkalaemic periodic paralysis (HPP) affects a highly conserved phenylalanine residue in an unexplored region of the alpha-subunit. This mutation was introduced into the rat skeletal muscle Na+ channel gene at the corresponding location (i.e. F...
Topics
- Animals
- Electrophysiology
- Female
- Horse Diseases
- Horses
- Ion Channel Gating
- Membrane Potentials
- Muscle, Skeletal
- Mutagenesis, Site-Directed
- Mutation
- Oocytes
- Paralyses, Familial Periodic
- Phenotype
- Rats
- Sodium Channels
- Transfection
- Xenopus laevis