Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

doi:10.1002/j.1460-2075.1993.tb06062.x

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Article

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

The EMBO journal - 1 Oct 1993

Perkins A C, Cory S

Abstract excerpt

The murine myelomonocytic cell line WEHI-3B exhibits ectopic expression of the genes encoding the homeobox protein, Hox-2.4, and the myeloid growth factor, interleukin-3 (IL-3). We showed previously that concomitant expression of IL-3 and Hox-2.4 in bone marrow cells induced the development of tr...

Topics

Animals
Bone Marrow Cells
Cell Division
Cell Transformation, Neoplastic
DNA-Binding Proteins
Fibroblasts
Genes, Homeobox
Hematopoietic Stem Cells
Homeodomain Proteins
Interleukin-3
Leukemia
Mast Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Megakaryocytes

Mice

Mice, Inbred C57BL

Mice, Inbred DBA

Monocytes

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8104786
DOI: 10.1002/j.1460-2075.1993.tb06062.x
PMCID: PMC413667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8104786-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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