Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells.

doi:10.1016/j.exphem.2006.11.008

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Article

Bcl-2 and Bcl-XL are indispensable for the late phase of mast cell development from mouse embryonic stem cells.

Experimental hematology - 1 Mar 2007

Möller Christine, Karlberg Mats, Abrink Magnus, Nakayama Keiichi I, Motoyama Noboru, Nilsson Gunnar

Abstract excerpt

OBJECTIVE: The aim of this study was to determine the importance of the prosurvival factors Bcl-2 and Bcl-XL for mast cell development and survival. METHODS: bcl-x(-/-) and bcl-2(-/-) mouse embryonic stem cells were maintained in medium supplemented with either interleukin (IL)-3 or IL-3 in combination with stem cell factor (SCF) to favor mast cell development. The development of Bcl-2 family deficient embryonic...

Topics

Animals
Cell Differentiation
Cell Proliferation
Cell Survival
Cells, Cultured
Gene Expression Profiling
Genotype
Interleukin-3
Mast Cells
Mice
Mice, Knockout
Minor Histocompatibility Antigens
Proto-Oncogene Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-bcl-2

RNA, Messenger

Reverse Transcriptase Polymerase Chain Reaction

Stem Cell Factor

Stem Cells

Source

Open in PubMed

Identifiers

PMID: 17309819
DOI: 10.1016/j.exphem.2006.11.008

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