Establishment of a novel factor-dependent myeloid cell line from primary cultures of mouse bone marrow.

doi:10.1016/1043-4666(91)90011-2

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Article

Establishment of a novel factor-dependent myeloid cell line from primary cultures of mouse bone marrow.

Cytokine - 1 Jan 1991

Hawley T S, McLeish W A, Hawley R G

Abstract excerpt

We describe here a novel myelomonocytic cell line (OTT1) obtained from primary cultures of mouse bone marrow cells infected with a retroviral vector carrying the mouse interleukin (IL)-1 alpha gene. OTT1 cells are dependent for their survival and proliferation on IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF) or, unexpectedly, IL-5. Despite their IL-5 dependency, OTT1 cells form colonies showing...

Topics

Animals
Bone Marrow
Bone Marrow Cells
Cell Division
Cell Line
Cell Survival
Cell Transformation, Neoplastic
Cells, Cultured
Cytokines
Female
Genetic Vectors
Granulocyte-Macrophage Colony-Stimulating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-1

Interleukin-3

Interleukin-5

Mice

Mice, Inbred C57BL

Phagocytosis

Source

Open in PubMed

Identifiers

PMID: 1883955
DOI: 10.1016/1043-4666(91)90011-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1883955-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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