Article
Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri.
Journal of virology - 1 Mar 1997
Fickenscher H, Bökel C, Knappe A, Biesinger B, Meinl E, Fleischer B, Fleckenstein B, Bröker B M
Abstract excerpt
Based on sequence divergence in the transformation-relevant region, herpesvirus saimiri strains are classified into three subgroups. Only members of subgroup C transform human T lymphocytes to continuous interleukin-2-dependent growth in culture. In this study, human cord blood T cells were immortalized by using different subgroup C strains (C488, C484, and C139). The resulting T-cell lines represented different...
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