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Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Oct 2023

Yuxiong Wang, Faping Li, Bin Liu, Yanghe Zhang, Yao Li, Yunkuo Li, Yishu Wang, Honglan Zhou

Abstract excerpt

The CREB3 family of proteins, encompassing CREB3 and its four homologs (CREB3L1, CREB3L2, CREB3L3, and CREB3L4), exerts pivotal control over cellular protein metabolism in response to unfolded protein reactions. Under conditions of endoplasmic reticulum stress, activation of the CREB3 family occurs through regulated intramembrane proteolysis within the endoplasmic reticulum membrane. Perturbations in the function...

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PMID: 37595431
DOI: 10.1016/j.biopha.2023.115335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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