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CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models

1 Feb 2011

Abstract excerpt

The CREB3 subfamily of membrane-bound bZIP transcription factors has five members in mammals known as CREB3 and CREB3L1-L4. One current model suggests that CREB3 subfamily transcription factors are similar to ATF6 in regulated intramembrane proteolysis and transcriptional activation. Particularly, they were all thought to be proteolytically activated in response to endoplasmic reticulum (ER) stress to stimulate...

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PMID: 21711675
DOI: 10.1186/2045-3701-1-6

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