Article
Genetic alterations in thyroid tumor progression: association with p53 gene mutations.
Japanese journal of cancer research : Gann - 1 May 1993
Ito T, Seyama T, Mizuno T, Tsuyama N, Hayashi Y, Dohi K, Nakamura N, Akiyama M
Abstract excerpt
To identify the genetic events that must be involved in thyroid tumor progression, we initially investigated p53 gene alterations in 10 papillary adenocarcinomas, 4 follicular adenocarcinomas, and 8 undifferentiated carcinomas. Base substitutional mutations in exons 5 to 8 and loss of heterozygos...
Topics
- Adenocarcinoma
- Adenocarcinoma, Papillary
- Base Sequence
- Carcinoma
- Chromosome Deletion
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Thyroid Neoplasms
- Tumor Cells, Cultured