Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.

doi:10.1136/thx.50.6.645

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Article

Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.

Thorax - 1 Jun 1995

Stolk J, Camps J, Feitsma H I, Hermans J, Dijkman J H, Pauwels E K

Abstract excerpt

BACKGROUND: The neutrophil elastase inhibitor, secretory leucocyte protease inhibitor (SLPI), is a potential therapeutic tool in inflammatory lung diseases such as cystic fibrosis and pulmonary emphysema. The distribution and disappearance in the lung of aerosolised recombinant SLPI (rSLPI) was investigated in healthy humans and in patients with cystic fibrosis or alpha 1-antitrypsin-associated emphysema....

Topics

Adult
Aerosols
Animals
Cricetinae
Cystic Fibrosis
Half-Life
Humans
Lung
Male
Mesocricetus
Phenotype
Proteinase Inhibitory Proteins, Secretory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proteins

Pulmonary Emphysema

Radionuclide Imaging

Recombinant Proteins

Secretory Leukocyte Peptidase Inhibitor

Serine Proteinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 7638807
DOI: 10.1136/thx.50.6.645
PMCID: PMC1021265

Genes

SLPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7638807-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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