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Article

Two Gene Fragments that Direct Podocyte-Specific Expression in Transgenic Mice

1 Jun 2002

Abstract excerpt

Transgenic manipulation of the glomerular visceral epithelial cell offers a powerful approach for studying the biology of this morphologically complex cell type. It has been previously demonstrated that an 8.3-kb and a 5.4-kb fragment of the murine Nphs1 (nephrin) promoter-enhancer drives lacZ expression in podocytes, brain, and pancreas of transgenic mice, recapitulating the expression pattern of the endogenous...

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PMID: 12039985
DOI: 10.1097/01.asn.0000015614.68893.0b

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