Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome.

doi:10.1016/0092-8674(90)90008-3

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome.

Cell - 10 Aug 1990

Weiher H, Noda T, Gray D A, Sharpe A H, Jaenisch R

Abstract excerpt

Transgenic mouse strains carrying proviruses were generated by exposing mouse embryos to a recombinant retrovirus. Animals carrying a single provirus were intercrossed to derive mice homozygous for a given proviral insertion. Adult mice homozygous for the Mpv17 integration developed nephrotic syndrome and chronic renal failure. Histologically, affected kidneys showed progressive glomerular sclerosis. Similar...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Chromosome Mapping
Cloning, Molecular
DNA
DNA Transposable Elements
Disease Models, Animal
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glomerulonephritis

Glomerulosclerosis, Focal Segmental

Homozygote

Kidney Failure, Chronic

Kidney Glomerulus

Membrane Proteins

Mice

Source

Open in PubMed

Identifiers

PMID: 1696177
DOI: 10.1016/0092-8674(90)90008-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1696177-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome.PMID 1696177Read ↗

Functional rescue of the glomerulosclerosis phenotype in Mpv17 mice by transgenesis with the human Mpv17 homologue.Semantic proximity Read ↗

Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRINSemantic proximity Read ↗

Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats.Semantic proximity Read ↗

Inner ear defect similar to Alport's syndrome in the glomerulosclerosis mouse model Mpv17.Semantic proximity Read ↗

Expression of the orpk disease gene during kidney development and maturation.Semantic proximity Read ↗

An abundant placental transcript containing an IAP-LTR is allelic to mouse pregnancy-specific glycoprotein 23 (Psg23): cloning and genetic analysis.Semantic proximity Read ↗

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.Semantic proximity Read ↗

Tubular-specific expression of HIV protein Vpr leads to severe tubulointerstitial damage accompanied by progressive fibrosis and cystic developmentSemantic proximity Read ↗

Gene expression in kidney using transgenic approaches.Semantic proximity Read ↗

An activated allele of the c-erbB-2 oncogene impairs kidney and lung function and causes early death of transgenic mice.Semantic proximity Read ↗

A model of polycystic kidney disease in SBM transgenic mice.Semantic proximity Read ↗

Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.