Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel genetically engineered mouse models for clear cell renal cell carcinoma.

Scientific reports - 22 May 2023

van der Mijn Johannes C, Laursen Kristian B, Fu Leiping, Khani Francesca, Dow Lukas E, Nowak Dawid G, Chen Qiuying, Gross Steven S, Nanus David M, Gudas Lorraine J

Abstract excerpt

Genetically engineered mouse models (GEMMs) are important immunocompetent models for research into the roles of individual genes in cancer and the development of novel therapies. Here we use inducible CRISPR-Cas9 systems to develop two GEMMs which aim to model the extensive chromosome p3 deletion frequently observed in clear cell renal cell carcinoma (ccRCC). We cloned paired guide RNAs targeting early exons of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Renal Cell
Share to Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Neoplasms

Share to Mutation

Share to Promoter Regions, Genetic

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 37217526
DOI: 10.1038/s41598-023-35106-7
PMCID: PMC10203127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel genetically engineered mouse models for clear cell renal cell carcinoma.PMID 37217526Read ↗

Generation of autochthonous mouse models of clear cell renal cell carcinoma: mouse models of renal cell carcinoma.Semantic proximity Read ↗

Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesisSemantic proximity Read ↗

Novel mouse reporter models for the detection of genome editing events in vivoSemantic proximity Read ↗

Genetic and metabolic hallmarks of clear cell renal cell carcinoma.Semantic proximity Read ↗

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.Semantic proximity Read ↗

Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.Semantic proximity Read ↗

In vivo base editing rescues ADPKD in a humanized mouse model.Semantic proximity Read ↗

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumorsSemantic proximity Read ↗

Generation of a Mouse Model of Von Hippel–Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1αSemantic proximity Read ↗

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinomaSemantic proximity Read ↗

9p21 Loss Defines the Evolutionary Patterns of Aggressive Renal Cell CarcinomasSemantic proximity Read ↗

A modified TALEN-based strategy for rapidly and efficiently generating knockout mice for kidney development studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.