Article
A fluorescence reporter model defines "Tip-DCs" as the cellular source of interferon β in murine listeriosis.
PloS one - 16 Dec 2010
Dresing Philipp, Borkens Stephanie, Kocur Magdalena, Kropp Sonja, Scheu Stefanie
Abstract excerpt
Production of type I interferons, consisting mainly of multiple IFNα subtypes and IFNβ, represents an essential part of the innate immune defense against invading pathogens. While in most situations, namely viral infections, this class of cytokines is indispensable for host survival they mediate a detrimental effect during infection with L. monocytogenes by rendering macrophages insensitive towards IFNγ...
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