Article
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
Punnonen J, Aversa G, Cocks B G, McKenzie A N, Menon S, Zurawski G, de Waal Malefyt R, de Vries J E
Abstract excerpt
Recently the cDNA encoding interleukin 13 (IL-13), a T-cell-derived cytokine, was cloned and expressed. The present study demonstrates that IL-13 induces IgG4 and IgE synthesis by human B cells. IL-13-induced IgG4 and IgE synthesis by unfractionated peripheral blood mononuclear cells and highly p...
Topics
- Antibodies, Monoclonal
- Antibody Formation
- Antigens, CD
- B-Lymphocytes
- Cell Membrane
- Cells, Cultured
- Humans
- Immunoglobulin E
- Immunoglobulin G
- Immunoglobulin Isotypes
- Immunoglobulin epsilon-Chains
- Interferon Type I
- Interferon-gamma
- Interleukin-13