Article
Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
Punnonen J, Aversa G, Cocks B G, McKenzie A N, Menon S, Zurawski G, de Waal Malefyt R, de Vries J E
Abstract excerpt
Recently the cDNA encoding interleukin 13 (IL-13), a T-cell-derived cytokine, was cloned and expressed. The present study demonstrates that IL-13 induces IgG4 and IgE synthesis by human B cells. IL-13-induced IgG4 and IgE synthesis by unfractionated peripheral blood mononuclear cells and highly purified B cells cultured in the presence of activated CD4+ T cells or their membranes. IL-13-induced IgG4 and IgE...
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