Article
Defective calcium response in B-chronic lymphocytic leukemia cells. Alteration of early protein tyrosine phosphorylation and of the mechanism responsible for cell calcium influx.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1993
Michel F, Merle-Béral H, Legac E, Michel A, Debré P, Bismuth G
Abstract excerpt
To study defective signal transduction via the Ag receptor of B-chronic lymphocytic leukemia cells (B-CLL), we examine in this report the Ca2+ response triggered by anti-mu antibody in 23 patients previously classified in three phenotypic groups. Altered Ca2+ changes are essentially found in CLL...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Antibodies, Monoclonal
- Antigens, CD
- CD11 Antigens
- Calcium
- Humans
- Immunoglobulin M
- Leukemia, Lymphocytic, Chronic, B-Cell
- Phenotype
- Phosphorylation
- Proteins
- Rabbits
- Receptors, Antigen, B-Cell
- Terpenes
- Thapsigargin
- Tyrosine