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Article

Basal Ca(2+) signaling is particularly increased in mutated chronic lymphocytic leukemia.

Leukemia - 1 Feb 2015

Muggen A F, Pillai S Y, Kil L P, van Zelm M C, van Dongen J J M, Hendriks R W, Langerak A W

Abstract excerpt

On the basis of somatic hypermutation status of their B-cell antigen receptor (BCR) genes, chronic lymphocytic leukemia (CLL) patients can be divided into unmutated CLL (U-CLL) or mutated CLL (M-CLL). Approximately 30% of CLL patients express a stereotypic BCR, which may indicate that specific antigenic stimulation is driving CLL pathogenesis. Recently, it was reported that BCRs from CLL cells are capable of...

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Identifiers

PMID: 24917358
DOI: 10.1038/leu.2014.188

Genes

BCR

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