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Article

Activating mutations in JAK2 and CALR differentially affect intracellular calcium flux in store operated calcium entry.

Cell communication and signaling : CCS - 21 Mar 2024

Bhuria Vikas, Franz Tobias, Baldauf Conny, Böttcher Martin, Chatain Nicolas, Koschmieder Steffen, Brümmendorf Tim H, Mougiakakos Dimitrios, Schraven Burkhart, Kahlfuß Sascha, Fischer Thomas

Abstract excerpt

BACKGROUND: Calcium (Ca2+) signaling regulates various vital cellular functions, including integrin activation and cell migration. Store-operated calcium entry (SOCE) via calcium release-activated calcium (CRAC) channels represents a major pathway for Ca2+ influx from the extracellular space in multiple cell types. The impact of JAK2-V617F and CALR mutations which are disease initiating in myeloproliferative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38509561
DOI: 10.1186/s12964-024-01530-z
PMCID: PMC10956330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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