No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease.

doi:10.1006/bbrc.1994.2245

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Article

No association of mutations at nucleotide 5460 of mitochondrial NADH dehydrogenase with Alzheimer's disease.

Biochemical and biophysical research communications - 15 Sept 1994

Kösel S, Egensperger R, Mehraein P, Graeber M B

Abstract excerpt

NADH dehydrogenase (EC 1.6.99.3) mutations at nucleotide 5460 of mitochondrial DNA (codon 331 of the ND2 subunit gene) have been associated with Alzheimer's disease (BBRC 182, 238-246, 1992; BBRC 189, 1202-1206, 1992). We have sequenced codons 304-347 of this gene in 15 neuropathologically confir...

Topics

Aged
Alzheimer Disease
Base Sequence
DNA, Mitochondrial
Female
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
NADH Dehydrogenase
Polymerase Chain Reaction

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