Article
Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains.
Biochemical and biophysical research communications - 15 Jan 1992
Lin F H, Lin R, Wisniewski H M, Hwang Y W, Grundke-Iqbal I, Healy-Louie G, Iqbal K
Abstract excerpt
Point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 (ND2) were detected in 10 of 19 Alzheimer's brains but not in 11 normal brains. The same mutations were also detected in 2 of 6 patients with amyotrophic lateral sclerosis (ALS). However, neurofibrillary tangles and neurit...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amino Acid Sequence
- Base Sequence
- Cerebral Cortex
- Codon
- DNA, Mitochondrial
- Gene Library
- Humans
- Middle Aged
- Mitochondria
- Molecular Sequence Data
- Mutation
- NADH Dehydrogenase
- Oligodeoxyribonucleotides
- Poly A