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Article

HIV-1 Nef protein in the nucleus influences adipogenesis as well as viral transcription through the peroxisome proliferator-activated receptors

1 Jan 2004

Abstract excerpt

BACKGROUND: Although the HIV-1 Nef protein (27 kDa) localizes primarily in cytoplasm, there is considerable evidence suggesting its occasional localization in the nucleus. Nef is known to play an important role in transcriptional events and viral replication, but the actual target of Nef in the nucleus remains to be identified. OBJECTIVE: To examine the functional roles of Nef in the nucleus and its possible...

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PMID: 15075535
DOI: 10.1097/00002030-200401230-00007

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