Article
Repression by a differentiation-specific factor of the human cytomegalovirus enhancer.
Nucleic acids research - 1 May 1996
Huang T H, Oka T, Asai T, Okada T, Merrills B W, Gertson P N, Whitson R H, Itakura K
Abstract excerpt
We detected a novel nuclear protein, MRF, that binds to multiple sites on the modulator which is located upstream of the human cytomegalovirus major immediate early gene enhancer. The expression of MRF is differentiation specific; the DNA binding activity is present in nuclear extracts from undif...
Topics
- Base Composition
- Base Sequence
- Binding Sites
- Binding, Competitive
- Cell Differentiation
- Cell Line
- Cytomegalovirus
- DNA, Viral
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation, Viral
- Genes, Immediate-Early
- Humans
- Molecular Sequence Data
- Mutation
- Repressor Proteins