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Article

Phospholipases C are involved in the virulence of Mycobacterium tuberculosis.

Molecular microbiology - 1 Jul 2002

Raynaud Catherine, Guilhot Christophe, Rauzier Jean, Bordat Yann, Pelicic Vladimir, Manganelli Riccardo, Smith Issar, Gicquel Brigitte, Jackson Mary

Abstract excerpt

Phospholipases C play a role in the pathogenesis of several bacteria. Mycobacterium tuberculosis, the causative agent of tuberculosis, possesses four genes encoding putative phospholipases C, plcA, plcB, plcC and plcD. However, the contribution of these genes to virulence is unknown. We constructed four single mutants of M. tuberculosis each inactivated in one of the plc genes, a triple plcABC mutant and a...

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Identifiers

PMID: 12100560
DOI: 10.1046/j.1365-2958.2002.03009.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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