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Article

Improvement of the applicability of carboxypeptidase Y in peptide synthesis by protein engineering.

Peptide research - 1 Jan 2000

Raaschou-Nielsen M, Mortensen U H, Olesen K, Breddam K

Abstract excerpt

Asn51 and Glu145 of (serine) carboxypeptidase Y function as binding sites for the C-terminal carboxylate group of peptide substrates, and Glu65 is involved in orienting these two amino acid residues. A series of mutants of carboxypeptidase Y where these three amino acid residues have been replaced were investigated for their applicability in transacylation reactions with amino acid esters as acceptors. With...

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PMID: 8081068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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