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Article

Improved Enantioselectivity of Subtilisin Carlsberg towards Secondary Alcohols by Protein Engineering.

Chembiochem : a European journal of chemical biology - 16 Feb 2018

Dorau Robin, Görbe Tamás, Svedendahl Humble Maria

Abstract excerpt

Generally, the catalytic activity of subtilisin Carlsberg (SC) for transacylation reactions with secondary alcohols in organic solvent is low. Enzyme immobilization and protein engineering was performed to improve the enantioselectivity of SC towards secondary alcohols. Possible amino-acid residues for mutagenesis were found by combining available literature data with molecular modeling. SC variants were created...

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PMID: 29105250
DOI: 10.1002/cbic.201700408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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