Article
The apolipoprotein E epsilon 4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutations.
Annals of neurology - 1 Sept 1994
Haan J, Van Broeckhoven C, van Duijn C M, Voorhoeve E, van Harskamp F, van Swieten J C, Maat-Schieman M L, Roos R A, Bakker E
Abstract excerpt
In 31 symptomatic and 5 asymptomatic carriers of the amyloid precursor protein (APP) gene codon 693 mutation, 10 family members without mutation, and 5 carriers of the APP gene codon 692 mutation (3 with early-onset Alzheimer dementia, 2 with cerebral hemorrhage), a high frequency of the apolipop...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amyloid Neuropathies
- Amyloid beta-Protein Precursor
- Apolipoproteins E
- Brain
- Cerebral Hemorrhage
- Codon
- Female
- Genotype
- Humans
- Immunohistochemistry