Article
The different approaches to the genetic analysis of autoimmune thyroid disease.
The Journal of endocrinology - 1 Oct 1999
Allahabadia A, Gough S C
Abstract excerpt
Graves' disease and Hashimoto's thyroiditis are organ-specific autoimmune disorders of multifactorial aetiology with a polygenic mode of inheritance. Familial clustering and twin studies provide evidence for a genetic predisposition. Three main approaches have been used in the search for susceptibility loci: population-based case-control studies, classical linkage analysis, and intrafamilial linkage...
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