Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice.

1 Sept 1994

Abstract excerpt

To investigate diabetes resistance to T cell-mediated disease transfer, we administered islet-specific T cell clones to the F1 progeny of nonobese diabetic (NOD) mice that were crossed with various nondiabetes-prone inbred mouse strains. We investigated four diabetogenic CD4+ T cell clones and all induced insulitis and full development of diabetes in (SWR x NOD)F1, (SJL x NOD)F1, and (C57BL/6 x NOD)F1 mice. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Treatment and Management
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8077683
DOI: 10.4049/jimmunol.153.6.2800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice.PMID 8077683Read ↗

I-E+ nonobese diabetic mice develop insulitis and diabetes.Semantic proximity Read ↗

Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice.Semantic proximity Read ↗

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependentSemantic proximity Read ↗

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.Semantic proximity Read ↗

MHC-linked protection from diabetes dissociated from clonal deletion of T cells.Semantic proximity Read ↗

Regulation of Diabetes Development by Regulatory T Cells in Pancreatic Islet Antigen-Specific TCR Transgenic Nonobese Diabetic MiceSemantic proximity Read ↗

Specific destruction of islet transplants in NOD<-->C57BL/6 and NOD<-->C3H/Tif embryo aggregation chimeras irrespective of allelic differences in beta-cell antigens.Semantic proximity Read ↗

Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice.Semantic proximity Read ↗

Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.