Article
A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae.
Molecular microbiology - 1 May 1994
Guenzi E, Gasc A M, Sicard M A, Hakenbeck R
Abstract excerpt
Penicillin resistance in Streptococcus pneumoniae has been attributed so far to the production of penicillin-binding protein (PBP) variants with decreased affinities for beta-lactam antibiotics. Cefotaxime-resistant laboratory mutants, selected after several steps on increasing concentrations of...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Cefotaxime
- Chromosome Mapping
- DNA Mutational Analysis
- Drug Resistance, Microbial
- Histidine Kinase
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Penicillin Resistance
- Piperacillin
- Protein Kinases
- Sequence Analysis, DNA
- Sequence Homology, Amino Acid
- Signal Transduction
- Streptococcus pneumoniae