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Article

A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae.

Molecular microbiology - 1 May 1994

Guenzi E, Gasc A M, Sicard M A, Hakenbeck R

Abstract excerpt

Penicillin resistance in Streptococcus pneumoniae has been attributed so far to the production of penicillin-binding protein (PBP) variants with decreased affinities for beta-lactam antibiotics. Cefotaxime-resistant laboratory mutants, selected after several steps on increasing concentrations of this beta-lactam, become deficient in transformation as well. A DNA fragment conferring both cefotaxime resistance and...

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PMID: 8065267
DOI: 10.1111/j.1365-2958.1994.tb01038.x

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