Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).

Article

Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6).

The Journal of biological chemistry - 29 Apr 1994

Mollicone R, Reguigne I, Fletcher A, Aziz A, Rustam M, Weston B W, Kelly R J, Lowe J B, Oriol R

Abstract excerpt

While most humans express an alpha(1,3)-fucosyltransferase in plasma, 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of these plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cells, Cultured
DNA
Female
Fucosyltransferases
Humans
Indonesia
Male
Molecular Sequence Data
Mutation
Pedigree
Polymorphism, Genetic

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