Article
Estimation of Lewis-negative alleles by high-resolution melting analysis of three tag SNPs of FUT3.
Vox sanguinis - 1 Feb 2022
Soejima Mikiko, Koda Yoshiro
Abstract excerpt
BACKGROUND AND OBJECTIVES: The expression of type 1 chain Lewis blood group antigens is regulated by secretor-type α(1,2)fucosyltransferase, encoded by FUT2, and Lewis α(1,3/1,4)fucosyltransferase, encoded by FUT3. Accumulating evidence has linked Lewis phenotypes or genotypes to various clinical conditions. Thus, in addition to FUT2, large-scale FUT3 genotyping is important. Because FUT3 has two paralogous genes...
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