Article
Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.
Japanese journal of cancer research : Gann - 1 Jun 1994
Kusunoki Y, Hayashi T, Hirai Y, Kushiro J, Tatsumi K, Kurihara T, Zghal M, Kamoun M R, Takebe H, Jeffreys A
Abstract excerpt
Bloom's syndrome (BS) is an autosomal recessive disorder conferring high propensity for cancer and displaying a high degree of genetic instability; the frequency of sister chromatid exchange is characteristically 10 times above background. The symmetrical four-armed chromatid interchanges are muc...
Topics
- Adult
- Alleles
- Bloom Syndrome
- Cell Cycle
- Cells, Cultured
- Chromosomes, Human
- Female
- Flow Cytometry
- HLA-A Antigens
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Humans
- Male
- Middle Aged
- Mitosis