Article
Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.
Japanese journal of cancer research : Gann - 1 Jun 1994
Kusunoki Y, Hayashi T, Hirai Y, Kushiro J, Tatsumi K, Kurihara T, Zghal M, Kamoun M R, Takebe H, Jeffreys A
Abstract excerpt
Bloom's syndrome (BS) is an autosomal recessive disorder conferring high propensity for cancer and displaying a high degree of genetic instability; the frequency of sister chromatid exchange is characteristically 10 times above background. The symmetrical four-armed chromatid interchanges are much more readily detected in peripheral blood lymphocytes of BS patients, suggesting that the frequency of somatic...
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