Article
Bloom's syndrome. XVIII. Hypermutability at a tandem-repeat locus.
Human genetics - 1 Dec 1992
Groden J, German J
Abstract excerpt
D1Z2 is a highly polymorphic DNA locus composed of a tandem of repetitive units. Its molecular constitution has been examined in 61 clonal cell lines selected at random from two lymphoblastoid cell lines (LCLs), each of which had been proliferating in vitro for several hundred days. Thirty-three of the cells were selected from an LCL derived from the blood of a person with Bloom's syndrome (BS), and the others...
Topics
- Base Sequence
- Bloom Syndrome
- Cell Line, Transformed
- Child
- Chromosome Banding
- Chromosomes, Human, Pair 1
- DNA
- DNA Probes
- Humans
- Karyotyping
- Male
- Molecular Sequence Data